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Irina Alexandrovna Savvina, Professor, D.Med.Sci.

Affiliation: Almazov National Medical Research Centre of Ministry of Health Care of Russian Federation

Education:
The First Saint Petersburg Pavlov Medical State University, Saint Petersburg. Residency in Anesthesiology and Intensive Care.
Postgraduate course in Anesthesiology and Intensive Care.

Business Address: 197341, 2 Akkuratova str., Saint Petersburg, Russian Federation

Research and Professional Experience:

Highly qualified anesthesiologist with 35 years of experience. Specialist in the field of Neuroanesthesiology and NeuroIntensive Care.
I am also committed to conducting scientific research in this area.

My scientific interest is in the study of septic encephalopathy, molecular genetic aspects of general anesthesia and systemic inflammation response during general anesthesia in neurosurgery including pediatric neurosurgery, personified premedication in neurosurgical patients.

In 1994, I defended my PhD thesis " Opioid anesthesia in pediatric neurosurgery", which describes the peculiarities of opioid anesthesia in pediatric patients with intracranial hypertension, intracranial pressure dynamics during induction of anesthesia in neurosurgical patients with brain tumor, hydrocephalus.

In 2000, I defended my doctoral dissertation on the topic " Anesthesia management system of neurosurgical operations and diagnostic proceeders in pediatric patients", which presents the structure of general anesthesia and choice of anesthetic agents according to the anesthetic influence on the stress-limiting antinociceptive neuroregulatory systems of the brain.
In 2001 I received the degree of Doctor of Medical Sciences.

Alongside with the research I performed duties of a clinical anesthesiologist.


Professional Appointments:

1987-1988 - postgraduate study at the First Saint Petersburg Pavlov Medical State University, anesthesiologist by profession.

In 1988, after my postgraduate study I got the position of a scientific researcher on a competitive basis of the Russian Polenov Scientific Research Neurosurgical Institute. For 30 years of my professional activity, I have gone from an junior researcher to the Chief Researcher.

2008-2010 - Head of the Research Department of Anesthesiology and Intensive Care of the
Research Institute of Children’s Infections, Saint Petersburg, Russian Federation

From 2001 to the present time – Professor of the Vladimir L. Vanevskii Department of Anaesthesiology and Reanimatology of the North-Western State Medical University named after Ilya I. Mechnikov of Ministry of Health Care of Russian Federation, Saint Petersburg, Russian Federation

Honors: I am awarded the medal “ To the 300th anniversary of St. Petersburg”, the medal “ For contribution to the development of science named after the nobel laureate Ivan P. Pavlov”, the medal “ Personality of St. Petersburg”.



  • Publications
    Publications from the Last 4 Years:
    2020
    1. Gurskaia V. I., Dryagina N. V., Ivanov V. P., Savvina I.A. General inhalation sevoflurane anesthesia effect on the inflammatory and brain damage biomarkers blood serum levels in the pediatric patients with craniosynostosis during MRI investigation: a cohort study. Science. Education. Practice: materials of the International University Science Forum (Canada, Toronto), April 22, 2020. - Infinity Publishing. - P. 119-124. DOI 10.34660/INF.2020.1.61638 URL http://naupers.ru/wp-content/uploads/2020/04/Canada-April-22- Part-2.pdf#page=119
    2. Savvina I., Orechova E., Gulyaev D. Personify premedication in the structure of general anesthesia in neurosurgical patients with intracranial neoplasm. European Journal of Anaesthesiology. - 2020.-Vol.37, suppl.58. - P. 182-183. www.ejanaesthesiology.com
    3. Savvina I.A., Lavrinenko N.V., Zabrodskaya Yu. M, Sebelev K. I., Dolmatov.V. Hippocampus role in the predictive assessment of sepsis development in patients with severe traumatic brain injury. European Journal of Anaesthesiology. - 2020.-Vol.37, suppl.58. - P. 302-303. www.ejanaesthesiology.com
    4. Savvina I., Anna Petrova, Roman Rutkovskiy, Ekaterina Orechova, Sergey Mertsalov, Anna Novikova. Selective decontamination of the intestine in neurosurgical patients with subarachnoid hemorrhage in the acute period of cerebral aneurysm rupture/ European Journal of Anaesthesiology, June 2020.-Vol.37, e-Suppl. 58. - P. 274-275. www.ejanaesthesiology.com
    5. Savvina I.A, Alexandrovich Yu S, Lekmanov A.U, Semenova Zh. B Khachatryan V.A. Management of Pediatric Severe Traumatic Brain Injury: What are News? EC Anaesthesia. – 2020. – Vol.6, №10. – Р. 1-14. https://www.ecronicon.com/anaesthesia.php
    6. Atiskov YuA, Akshulakov SK, Belkin AA, Kondratiev AN, Larionov SN, Nazaralieva ET, Riznich VP, Savvina IA, Safin ISh, Khachatryan VA. Craniospinal compliance — new principles for intracranial pressure monitoring. Russian Journal of Anaesthesiology and Reanimatology. 2020;(6):37-43. https://doi.org/10.17116/anaesthesiology202006137

    2021

    1. Savvina IA, Kondratieva EA, Grekhov EV, Morozov KA, Biktasheva LZ, Gurskaya VI, Stepanova KV, Novikov VYu, Kim AV, Lebedev KE, Sereda EO, Ryzhkov AV, Efimtsev AYu, Trufanov GE, Ryzhkova DV, Pervunina TM, Khachatryan VA, Shlyakhto EV. Consciousness recovery in a child with hypoxic brain damage after surgical treatment of congenital heart disease. Russian Journal of Anaesthesiology and Reanimatology. 2021;(1):81-90. https://doi.org/10.17116/anaesthesiology202101181
    2. Gurskaya VI, Dryagina NV, Ivanov VP, Aleksandrovich YuS, Khachatryan VA, Savvina IA. Effect of general anesthesia on systemic inflammatory response and neuronal damage in children with craniosynostosis in the perioperative period. Russian Journal of Anaesthesiology and Reanimatology. 2021;(1):39-45. https://doi.org/10.17116/anaesthesiology202101139
    3. Gurskaya V.I., Ivanov V.P., Novikov V.Yu., Dryagina N.V., Savvina I. A. Systemic inflammatory response in infants with craniostenosis sedated with propofol. Russian Journal of Pediatric Surgery, Anesthesia, and Intensive Care. 2021;11(3): 297-306. DOI: https://doi.org/10.17816/psaic961
    4. Irina Alexandrovna Savvina, Anna Olegovna Petrova. The Treatment of Acute Stroke. / Ischemic Stroke/ Edited by Pratap Sanchetee/ IntechOpen, London.-2021. - 117 P. DOI: 10.5772/intechopen.86623 ISBN: 978-1-83962-395-0
    5. Irina Alexandrovna Savvina, Yulia Mihailovna Zabrodskaya, Anna Olegovna Petrova, Konstantin Alexandrovich Samochernykh. Cerebral vasospasm: Mechanisms, Pathomorphology, Diagnostics, Treatment / Cerebrovascular Diseases/ Edited by Patricia Bozzetto Ambrosi/ IntechOpen, London.- 2021. - 138 P. DOI: http://dx.doi.org/10.5772/intechopen.101229
    2022
    1. Aneurysmal Subarachnoid Hemorrhage: From Diagnosis to Treatment / Ed. by Irina Savvina. - Nova Science Publishers, New York. - 2022. – 266 P. Print ISBN 9798886972511; ISBN 9798886972986 (eBook) DOI: 10.52305/dngf4073
    2. Savvina I.A., Zabrodskaya Y.M., Petrova A.O., Rozhchenko L.V., Goroschenko S.A., Potemkina E.G., Samochernych K.A. Aneurysmal Subarachnoid Hemorrhage: From Diagnosis to Treatment / Aneurysmal Subarachnoid Hemorrhage: From Diagnosis to Treatment // Ed. by Irina Savvina. - Nova Science Publishers, NY. - 2022. – P. 41-112. Print ISBN 9798886972511; ISBN 9798886972986 (eBook)
    3. Savvina I.A., Petrova A.O. Anesthetic Management of Cerebral Aneurysm Surgery/Aneurysmal Subarachnoid Hemorrhage: From Diagnosis to Treatment // Ed. by Irina Savvina. - Nova Science Publishers, NY. - 2022. - P. 113-126. Print ISBN 9798886972511; ISBN 9798886972986 (eBook)
    4. Savvina I.A. Preface/ Aneurysmal Subarachnoid Hemorrhage: From Diagnosis to Treatment // Ed. by Irina Savvina.- Nova Science Publishers, NY. - 2022. – ix-x. Print ISBN 9798886972511; ISBN 9798886972986 (eBook)
    5. Irina A. Savvina, Daria V. Ryzhkova, Kristina M. Bykova, Konstantin E. Lebedev, Anna O. Petrova, Natalya V. Dryagina, Elena G. Potemkina and Eleonora T. Nazaralieva. Diagnostics of Central and Autonomic Nervous System Dysfunction in Patients with Sepsis-Associated Encephalopathy /Sepsis - new perspectives// Edit. By Dr. Lixing Huang, Dr. Youyu Zhang and Dr. Lingbin Sun. London: IntechOpen, 2022. DOI: 10.5772/intechopen.108392
    6. Bykova K.M., Savvina I.A., Bodareva N.V., Zabrodskaya Yu.M. Pathophysiological aspects and complex diagnosis of sepsis-associated encephalopathy. Prospects of etiopathogenetic therapy / Russian Journal of Anesthesiology and Resuscitation. 2022; (4): 92-98.
    7. Bykova K.M., Savvina I.A., Rutkovskiy R.V., Rodchenko A.M. The role of neuroinflammation in the brain dysfunction during the perioperative period / Russian Journal of Anesthesiology and Resuscitation. 2022; (6):99-106.
    8. Zabolotskikh I.B., Belkin A.A., Butrov A.V., Savvina I.A., et al. Perioperative management of patients with neuromuscular diseases. Russian Journal of Anesthesiology and Resuscitation. 2022; (6): 6-28.
    9. Clinical recommendations of Ministry of Health Care of Russian Federation "Traumatic brain injury in children". Semenova Zh.B., Melnikov A.V., Mescheryakov S.V., Akhadov T.A., Savvina I.A., Lekmanov A.U., et al. 2022. - 93 p. https://apicr.minzdrav.gov.ru
    10. Savvina I.A. Intensive care of stroke. St.Petersburg: Publishing house of the North-Western State Medical University named after Ilya I. Mechnikov, 2022. – 44 p.
    11. Bairova T.V., Savvina I.A. Selected questions of pediatric intensive care. St.Petersburg: Publishing house of the North-Western State Medical University named after Ilya I. Mechnikov, 2022. – 92 p.
    12. Irina Alexandrovna Savvina, Yulia Mihailovna Zabrodskaya, Anna Olegovna Petrova, Konstantin Alexandrovich Samochernykh. Cerebral vasospasm: Mechanisms, Pathomorphology, Diagnostics, Treatment / In: Cerebrovascular Diseases — elucidating Key Principles/ Edited by Dr. Patricia Bozzetto Ambrosi// IntechOpen, London. - 2022. - 138 P. DOI: http://dx.doi.org/10.5772/intechopen.101229
    13. Irina Alexandrovna Savvina, Yulia Mihailovna Zabrodskaya, Anna Olegovna Petrova. General anesthesia and autonomic nervous system: control and management in neurosurgery/ In: Autonomic Nervous System – Special Interest Topics / Edited by Dr. Theodoros Aslanidis and M.Sc. Christos Nouris// IntechOpen, London. - 2022. - 135 P. DOI: http://dx.doi.org/10.5772/intechopen.101829
    14. Sinbukhova E.V., Protsenko D.N., Lubnin A.Yu., Savvina I.A., Tyurin I.N. Happiness of anesthesiology and intensive care staff in the contex of life satisfaction and burnout. Russian Journal of Anesthesiology and Resuscitation. 2022;(1): 76-83. DOI: 10.17116/anaesthesiology202201176. https://istina.msu.ru/publications/article/435003068/
    15. Irina A. Savvina, Hasaybat S. Nutsalova, Anna O. Petrova, Kristina M. Bykova and Irina V. Tkebuchava. Replacement Selenium Therapy in Acute Cerebral Damage. In: Selenium and Human Health. Book edited by: Dr. Volkan Gelen. IntechOpen, London. — 22 p. DOI: http://dx.doi.org/10.5772/intechopen.110505

    2023
    1. Tatiana A. Petrova, Sergey A. Kondratyev, Anna A. Kostareva, Roman V. Rutkovskiy, Irina A. Savvina and Ekaterina A. Kondratyeva. miR-21, miR-93, miR-191, miR-let-7b, and miR-499 Expression Level in Plasma and Cerebrospinal Fluid in Patients with Prolonged Disorders of Consciousness. Neurol. Int. 2023; 15(1): 40–54. https://doi.org/10.3390/neurolint15010004 28/ 
    2. Bykova К.М., Zharova Е.N., Kasherininov I.Yu., Matakaeva Zh.А., Marichev А.О., Savvina I.А. Clinical significance of multimodal evoked potentials in patients with septic encephalopathy. Russian Journal of Anaesthesiology and Reanimatology. 2023; (6): 43-51.
    3. Bykova, K. Case of successful treatment of acute respiratory distress syndrome in the parturient woman with systemic lupus erythematosus and cerebral cyst of the third ventricular complicated by posterior reversible encephalopathy syndrome/ Kristina Bykova, Igor´ Kasherininov, Andrey Bautin, Irina Savvina // Journal of Internal Medicine and Health Affairs. – 2023. – Vol.2. – Issue 4. – P. 1-3. DOI: https://doi.org/10.58489/2836-2411/023
    4. Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels. – New-York: Nova Science Publishers. – 2023. – 300 p. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    5. Savvina I.A. Preface/ Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels. – New-York: Nova Science Publishers// Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – ix-x. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    6. Irina A. Savvina, Kristina M. Bykova, Anna O. Petrova. Modern conception about the pathogenesis of sepsis-associated encephalopathy/In: Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels // Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – P. 1-22. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    7. Irina A. Savvina, Кristina М. Bykova, Eleonora T. Nazaralieva. Clinical assessment of sepsis-associated encephalopathy / In: Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels // Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – P. 65-86. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    8. Elena N. Zharova, Irina A. Savvina, Konstantin E. Lebedev, Kristina M. Bykova. Neurophysiological assessment of sepsis-associated encephalopathy / In: Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels // Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – P. 87–108. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    9. Irina A. Savvina, Victoria I. Gurskaya, William A. Khachatryan, Eleonora T. Nazaralieva. Features of sepsis-associated encephalopathy in children / In: Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels // Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – P. 169–192. Print ISBN: 979-8-89113-178-1;PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    10. Irina A. Savvina, Kristina M. Bykova, Victoria I. Gurskaya. Therapeutic tactics in sepsis-associated encephalopathy: present and prospects / In: Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels // Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – P. 193–202. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0
    11. Irina A. Savvina, Kristina M. Bykova, Eleonora T. Nazaralieva. Molecular genetic aspects of diagnosis and clinical approaches of sepsis-associated encephalopathy / In: Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels // Ed. by Irina A. Savvina, Natalia V. Beloborodova and Tatyana N. Trofimova. – New-York: Nova Science Publishers. – 2023. – P. 219-226. Print ISBN: 979-8-89113-178-1; PDF ISBN: 979-8-89113-398-3; ePUB ISBN: 979-8-89113-399-0



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